Research Nutraceutical Supplements

PYRROLOQUINOLINE QUINONE

PYRROLOQUINOLINE QUINONE

Title:

Description:

PYRROLOQUINOLINE QUINONE

Category
Anti-Inflammatory, Boosts Cellular Energy, Inhibits Long-Term Disease, Inhibits Long-Term Side Effects, Protects Mitochondria, Restores Mitochondria
Pyrroloquinoline Quinone (PQQ) Protects Mitochondrial Function

30 trillion cells make up our bodies and inside every cell is a power plant called Mitochondria producing ALL the energy used by our bodies. Mitochondria are the Heart & Soul of the Body and Glutathione is the Sergeant at Arms of the immune system, the Master Guardian of Mitochondria and all Energy and Life. Pyrroloquinoline Quinone (PQQ) helps in the recovery of damaged mitochondria and development of new Mitochondria to continue producing adenosine triphosphate (ATP) energy at higher levels.

ABSTRACT
Pyrroloquinoline quinone (PQQ) is a novel supplement involved in processes such as mitochondrial biogenesis and cellular energy metabolism. The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on Mitochondria biogenesis (the synthesis of substances by living organisms) and restoration.

DISCUSSION
PQQ is contained in fruits and vegetables, such as kiwi fruit, parsley, cocoa powder, fermented soybeans (Japanese natto) and green peppers, and in human breast milk. PQQ is a novel biofactor of physiological importance and has been reported to be involved in a variety of biological functions that are clearly beneficial to survival, such as growth and fertility in newborns. It has also been reported to protect against glutamate-induced cell apoptosis (the process of programmed cell death) in primary cultured hippocampal neurons. PQQ is especially effective in neutralizing superoxide and hydroxyl radicals, which cause mitochondrial dysfunction, and it also antagonizes several types of oxidative stress-induced cell damage, including reoxygenation cardiac injury, chronic heart failure, ethanol-induced liver damage, and hyperoxia-induced cognitive deficits.

In this study, we demonstrated that PQQ has the potential to protect against oxidative stress-induced premature cellular senescence (a phenomenon characterized by the cessation of cell division) in auditory cells by enabling the recovery of mitochondrial function by restoring the regulation of SIRT1/PGC-1α, the protein expression of SIRT1, and the deacetylation of PGC-1α, and by facilitating the recovery of mitochondrial biogenesis including the adenosine triphosphate (ATP) energy production rate and maximum respiration rate. Restored SIRT1 leads to the mediation of PGC-1α and mitochondrial biogenesis in the auditory cells with oxidative stress-induced premature senescence. To our knowledge, this is the first report which indicates the effect of PQQ in protecting against the oxidative stress-induced premature cellular senescence of auditory cells.

In humans, dietary supplementation with PQQ recovers the antioxidant potential, attenuates the inflammatory response, and increases urinary metabolites related to mitochondrial functions. Considering these findings, the protective effect of PQQ in mitochondrial biogenesis is also expected for inner ear cells.

CITATION
(Gao Y., et.el., 2022). Nature Portfolio: Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence. Retrieved on 10/30/22 online from https://www.nature.com/articles/s41514-022-00083-0

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